Journal article
Environmental enrichment ameliorates behavioral impairments modeling schizophrenia in mice lacking metabotropic glutamate receptor 5
EL Burrows, CE McOmish, LS Buret, M Van Den Buuse, AJ Hannan
Neuropsychopharmacology | Published : 2015
DOI: 10.1038/npp.2015.44
Abstract
Schizophrenia arises from a complex interplay between genetic and environmental factors. Abnormalities in glutamatergic signaling have been proposed to underlie the emergence of symptoms, in light of various lines of evidence, including the psychotomimetic effects of NMDA receptor antagonists. Metabotropic glutamate receptor 5 (mGlu5) has also been implicated in the disorder, and has been shown to physically interact with NMDA receptors. To clarify the role of mGlu5-dependent behavioral expression by environmental factors, we assessed mGlu5 knockout (KO) mice after exposure to environmental enrichment (EE) or reared under standard conditions. The mGlu5 KO mice showed reduced prepulse inhibit..
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Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
We thank past and present laboratory members for useful discussions. Thank you to Maria Bastias, Daniel Drieberg, Ana Hudson, Maddison Lee Ible, Sally Martin, Brett Purcell, and Craig Thomson for their technical assistance. This work was funded by National Health Medical Research Council (NHMRC) project grant (APP1034785) to AJH. AJH has been supported by an Australian Research Council (ARC) FT3 Future Fellowship (FT100100835) and an NHMRC Senior Research Fellowship. CEM is supported by a NHMRC CJ Martin Overseas Biomedical Fellowship, and a Brain and Behavior Research Foundation Young Investigator Award. MvdB is supported by an NHMRC Senior Research Fellowship.